近期，来自中南大学湘雅二医院病理科的范松青教授等在新刊《Chinese Medical Journal Pulmonary and Critical Care Medicine》上发表了题为“Small cell lung cancer transformations from non-small cell lung cancer: Biological mechanism and clinical relevance”的综述文章，内容精彩，值得一读。摘要如下：

Lung cancer is a leading cause of cancer deaths worldwide, consisting of two major histological subtypes: small-cell lung cancer (SCLC) and non-small-cell lung cancer (NSCLC). In some cases, NSCLC patients may undergo a histological transformation to SCLC during clinical treatments, which is associated with resistance to targeted therapy, immunotherapy, or chemotherapy. The review provides a comprehensive analysis of SCLC transformation from NSCLC, including biological mechanism, clinical relevance, and potential treatment options after transformation, which may give a better understanding of SCLC transformation and provide support for further research to define better therapy options.

摘要的中文翻译如下：

肺癌是全球癌症死亡的主要原因，包括两种主要的组织学亚型：小细胞肺癌（SCLC）和非小细胞肺癌（NSCLC）。在某些情况下，NSCLC患者在临床治疗过程中可能会发生组织学转化为SCLC，这与靶向治疗、免疫治疗或化疗的耐药性有关。本综述对NSCLC转化为SCLC进行了全面分析，包括生物学机制、临床相关性和转化后的潜在治疗选择，这可能使人们更好地了解SCLC转化，并为进一步研究提供支持，以确定更好的治疗选择。

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全文链接：

https://www.sciencedirect.com/science/article/pii/S2772558823000610

Cite this article:

Yang Y, Fan S. Small cell lung cancer transformations from non-small cell lung cancer: Biological mechanism and clinical relevance. Chin Med J Pulm Crit Care Med. 2024;2(1):42-47.